Free sterol fractions were isolated from the marine sponges Phyllospongia madagascarensis, Scalarispongia sp., Oceanapia sp., Monanchora clathrata and studied by GLC, GLC-MS, and spectroscopy NMR. P. madagascarensis and Scalarispongia sp. contained common Delta(5)-sterols; cholesterol was shown to be a main sterol of both the sponges. Oceanapia sp. contained stanols and minor Delta(5)-sterols with 24R-24,25-methylene-5 alpha-cholestan-3 beta-ol as a main constituent. Many free sterols from M. clathrata were Delta(7)-series compounds, and latosterol was a main sterol. Delta(4)-3-Ketosteroids and Delta(5)-sterol esters were found in the Antarctic sponge Haliclona sp., but free sterols were practically absent except for trace amount of cholesterol. A chemotaxonomic application of sterols in relation to the genera Phyllospongia, Oceanapia and the family Crambeidae is provided. The known cases of the absence of sterols in sponges and probable reasons of the phenomenon are discussed. (c) 2007 Elsevier Ltd. All rights reserved.
Sterols and related metabolites from five species of sponges
Mollo Ernesto;Cimino Guido;
2007
Abstract
Free sterol fractions were isolated from the marine sponges Phyllospongia madagascarensis, Scalarispongia sp., Oceanapia sp., Monanchora clathrata and studied by GLC, GLC-MS, and spectroscopy NMR. P. madagascarensis and Scalarispongia sp. contained common Delta(5)-sterols; cholesterol was shown to be a main sterol of both the sponges. Oceanapia sp. contained stanols and minor Delta(5)-sterols with 24R-24,25-methylene-5 alpha-cholestan-3 beta-ol as a main constituent. Many free sterols from M. clathrata were Delta(7)-series compounds, and latosterol was a main sterol. Delta(4)-3-Ketosteroids and Delta(5)-sterol esters were found in the Antarctic sponge Haliclona sp., but free sterols were practically absent except for trace amount of cholesterol. A chemotaxonomic application of sterols in relation to the genera Phyllospongia, Oceanapia and the family Crambeidae is provided. The known cases of the absence of sterols in sponges and probable reasons of the phenomenon are discussed. (c) 2007 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
