An efficient and short enantioselective synthesis of (S)- and (R)-Tolterodine was performed by asymmetric hydrogenation of a coumarin intermediate, easily obtained by Heck reaction from cheap and commercially available starting material.
Enantioselective Synthesis of (S)- and (R)-Tolterodine by Asymmetric Hydrogenation of a Coumarin Derivative Obtained by a Heck Reaction
Fausta Ulgheri;Mauro Marchetti;
2007
Abstract
An efficient and short enantioselective synthesis of (S)- and (R)-Tolterodine was performed by asymmetric hydrogenation of a coumarin intermediate, easily obtained by Heck reaction from cheap and commercially available starting material.File in questo prodotto:
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