Roux-en-Y Gastric Bypass improves adiponectin to leptin ratio and inflammatory profile in severely obese women with and without metabolic syndrome: a randomized controlled trial

Obesity is a troubling public health problem as it increases risks of sleep disorders, respiratorycomplications, systemic arterial hypertension, cardiovascular diseases, type 2 diabetes mellitus,and metabolic syndrome (MetS). As a measure to counteract comorbidities associated with severeobesity, bariatric surgery stands out. This study aimed to investigate the adiponectin/leptin ratio inwomen with severe obesity with and without MetS who had undergone Roux-en-Y gastric bypass(RYGB) and to characterize the biochemical, glucose, and inflammatory parameters of blood inwomen with severe obesity before and after RYGB. Were enrolled females with severe obesity undergoingRYGP with MetS (n = 11) and without (n = 39). Anthropometric data and circulating levels ofglucose, total cholesterol, high-density lipoprotein (HDL), non-HDL total cholesterol, low-densitylipoprotein (LDL), adiponectin, and leptin were assessed before and 6 months after RYGB. Significantreductions in weight, body mass index, and glucose, total cholesterol, LDL, and leptin were observedafter surgery, with higher levels of HDL, adiponectin, and adiponectin/leptin ratio being observedafter surgery compared to the preoperative values of those. This study demonstrated that weight lossinduced by RYGB in patients with severe obesity with or without MetS improved biochemical andsystemic inflammatory parameters, particularly the adiponectin/leptin ratio.