The complex structure of aminobenzylnaphthols can be easily obtained with the useful Betti reaction. These valuable compounds can give rise to chiral intermediates, that found wide application in asymmetric synthesis. 1-[(1S)-(4-Fluorophenyl)-((1S)-1-naphthalen-1-yl-ethylamino)-methyl]naphthalen-2-ol 1 was treated with triflic anhydride to yield the corresponding (S,S)-triflate 2, which is a valuable intermediate in the future synthesis of aminophosphine, to be used in asymmetric catalysis. Keywords: Betti reaction; aminobenzylnaphthols; chirality; NMR analysis Preliminarily structural considerations based upon H(1)-NMR spectroscopy are also reported.
1-[(1S)-(4-Fluorophenyl)-((1?S)-1?-naphthalen-1-yl-ethylamino)-methyl]-naphthalen-2-trifluoromethanesulfonate
Cosimo Cardellicchio;
2023
Abstract
The complex structure of aminobenzylnaphthols can be easily obtained with the useful Betti reaction. These valuable compounds can give rise to chiral intermediates, that found wide application in asymmetric synthesis. 1-[(1S)-(4-Fluorophenyl)-((1S)-1-naphthalen-1-yl-ethylamino)-methyl]naphthalen-2-ol 1 was treated with triflic anhydride to yield the corresponding (S,S)-triflate 2, which is a valuable intermediate in the future synthesis of aminophosphine, to be used in asymmetric catalysis. Keywords: Betti reaction; aminobenzylnaphthols; chirality; NMR analysis Preliminarily structural considerations based upon H(1)-NMR spectroscopy are also reported.| File | Dimensione | Formato | |
|---|---|---|---|
|
prod_487180-doc_202359.pdf
accesso aperto
Descrizione: 1-[(1S)-(4-Fluorophenyl)-((1?S)-1?-naphthalen-1-yl-ethylamino)-methyl]-naphthalen-2-trifluoromethanesulfonate
Tipologia:
Versione Editoriale (PDF)
Licenza:
Creative commons
Dimensione
985 kB
Formato
Adobe PDF
|
985 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
