[Extract] Evidences were recently established [1] that ultra- high dose rates [2] delivered in short times by pulsed beams [3] (“FLASH” radiotherapy) spares healthy tissues preserving efficacy. The cell-level mechanism of this effect is poorly understood. Different hypotheses are considered: differential radicals’ production/depletion, or detoxify/recover pathways, different intra/ inter cellular diffusion of toxic substances/recovery signaling.
A MULTI-SCALE APPROACH TO THE FLASH EFFECT MODELING
Tozzini, V.;Castelli, L.;Monti, S.;
2023
Abstract
[Extract] Evidences were recently established [1] that ultra- high dose rates [2] delivered in short times by pulsed beams [3] (“FLASH” radiotherapy) spares healthy tissues preserving efficacy. The cell-level mechanism of this effect is poorly understood. Different hypotheses are considered: differential radicals’ production/depletion, or detoxify/recover pathways, different intra/ inter cellular diffusion of toxic substances/recovery signaling.File in questo prodotto:
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