Recruitment of natural antibodies towards tumour cells for their elimination by the immune system could be a highly specific and efficacious therapeutic strategy. While natural L-rhamnose has already been explored as a suitable antigen for antibody recruitment, we here report the first rhamnose-based glycomimetic to be used for such purpose. The glycomimetic is designed to be more hydrolytically and enzymatically stable than natural rhamnosides, provides a site for easy further conjugation and proved to capture anti-rhamnose IgG antibodies in serological ELISA assay.
Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies
Chiodo F.;
2022
Abstract
Recruitment of natural antibodies towards tumour cells for their elimination by the immune system could be a highly specific and efficacious therapeutic strategy. While natural L-rhamnose has already been explored as a suitable antigen for antibody recruitment, we here report the first rhamnose-based glycomimetic to be used for such purpose. The glycomimetic is designed to be more hydrolytically and enzymatically stable than natural rhamnosides, provides a site for easy further conjugation and proved to capture anti-rhamnose IgG antibodies in serological ELISA assay.File in questo prodotto:
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Descrizione: Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies
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