Stem cell-based embryo models have emerged as pioneering experimental models to study early mammalian embryogenesis using pluripotent stem cells. These models provide invaluable tools to study fundamental aspects of embryonic development and serve as platforms for disease modeling and drug screening1. Among the stem-cell based embryo models are gastruloids. Gastruloids are aggregates of defined numbers of embryonic stem cells that, under defined culture conditions, undergo symmetry breaking and recapitulate crucial events of gastrulation and axis formation2. I will introduce this topic and present some recent works of our group on the relationship between pluripotency and competence to develop gastruloids3 and how we can manipulate gastruloids to ask questions about how genes and cells interact to build an embryo4,5

STEM CELL-BASED EMBRYO MODELS: CHALLENGES AND OPPORTUNITIES FOR BASIC AND TRANSLATIONAL RESEARCH

Minchiotti Gabriella
2024

Abstract

Stem cell-based embryo models have emerged as pioneering experimental models to study early mammalian embryogenesis using pluripotent stem cells. These models provide invaluable tools to study fundamental aspects of embryonic development and serve as platforms for disease modeling and drug screening1. Among the stem-cell based embryo models are gastruloids. Gastruloids are aggregates of defined numbers of embryonic stem cells that, under defined culture conditions, undergo symmetry breaking and recapitulate crucial events of gastrulation and axis formation2. I will introduce this topic and present some recent works of our group on the relationship between pluripotency and competence to develop gastruloids3 and how we can manipulate gastruloids to ask questions about how genes and cells interact to build an embryo4,5
2024
Istituto di genetica e biofisica "Adriano Buzzati Traverso"- IGB - Sede Napoli
stem-cell base embryo models
gastruloids
File in questo prodotto:
File Dimensione Formato  
PROGRAMMA GEI 2024_18Maggio_DEF.pdf

accesso aperto

Licenza: Altro tipo di licenza
Dimensione 238.7 kB
Formato Adobe PDF
238.7 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/486107
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact