In the framework of our studies dealing with the synthesis and functionalization of biopolymers for nanomedicine,2-5 we have synthesized a novel three-arms star-PLA- PEG copolymer decorated with β-cyclodextrins (CD) and a novel adamantane-functionalized BODIPY (Ada-BODIPY) to be included by supramolecular interactions into the star-PLA-PEG to monitoring the in vitro cellular uptake and intracellular trafficking of the nanocarrier. The newly designed star-PLA-PEG- CD@Ada-BODIPY was prepared by a proper combination of copper-catalyzed click reaction and host- guest interaction.
Synthesis of BODIPY-labeled β-Cyclodextrin-grafted Star-PLA-PEG Copolymers
Burduja N.;Mazzaglia A;
2022
Abstract
In the framework of our studies dealing with the synthesis and functionalization of biopolymers for nanomedicine,2-5 we have synthesized a novel three-arms star-PLA- PEG copolymer decorated with β-cyclodextrins (CD) and a novel adamantane-functionalized BODIPY (Ada-BODIPY) to be included by supramolecular interactions into the star-PLA-PEG to monitoring the in vitro cellular uptake and intracellular trafficking of the nanocarrier. The newly designed star-PLA-PEG- CD@Ada-BODIPY was prepared by a proper combination of copper-catalyzed click reaction and host- guest interaction.File in questo prodotto:
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