Editorial: Mitochondrial plasticity and quality control in health and disease

Introduction Mitochondria play a multifaceted role in cellular physiology extending from the regulation of energy production and cell metabolism to calcium buffering and the modulation of intracellular signaling. Given that mitochondrial dysfunctions are involved in a spectrum of complex human pathologies and inheritable disorders, preserving a functional mitochondrial network is crucial for health and disease status and it has become a focal point of innovative therapeutic strategies. This Research Topic compiles articles focused on two primary areas of mitochondrial research: i) the investigation of mitochondrial dysfunction in various pathological conditions (including mitochondrial diseases) and the exploration of therapeutic interventions that target and/or exploit mitochondria; and ii) the elucidation of the crucial role of mitochondria in development and differentiation. Finally, this issue introduces a novel methodology that employs commercially available tools for the quantification of mitochondrial DNA and RNA within intact and complex tissues.