This study investigated the role of dorsal striatum in spatial memory in mice. The mice were tested for their ability to detect a spatialdisplacement 24 hr after training. In order to manipulate the dorsal striatum, focal administrations of the N-methyl-D-aspartate (NMDA antagonist D-2-amino-5 phosphonopentanoic acid (AP-5) were performed immediately after training. AP-5 impaired the mice's ability to detect the spatial change only if their initial position was constant during training and testing. These findings demonstrate that NMDA receptor blockade within the dorsal striatum impairs spatial memory consolidation in a task in which no explicit reward or procedural learning is involved. The results are discussed with reference to a possible selective involvement of this structure in processing spatial information acquired through an egocentric, but not an allocentric, frame of reference.
Pharmacological evidence of the role of dorsal striatum in spatial memory consolidation in mice.
De Leonibus E;
2003
Abstract
This study investigated the role of dorsal striatum in spatial memory in mice. The mice were tested for their ability to detect a spatialdisplacement 24 hr after training. In order to manipulate the dorsal striatum, focal administrations of the N-methyl-D-aspartate (NMDA antagonist D-2-amino-5 phosphonopentanoic acid (AP-5) were performed immediately after training. AP-5 impaired the mice's ability to detect the spatial change only if their initial position was constant during training and testing. These findings demonstrate that NMDA receptor blockade within the dorsal striatum impairs spatial memory consolidation in a task in which no explicit reward or procedural learning is involved. The results are discussed with reference to a possible selective involvement of this structure in processing spatial information acquired through an egocentric, but not an allocentric, frame of reference.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
