The addition of titanium and lithium enolates 1 and 2 to γ-alkoxy enone 4 occurs in good yield with good stereoselectivities. 3,4 syn - 2,3 syn adducts 7 are obtained starting from the lithium enolate 2, whereas the 3,4 syn - 2,3 anti isomers 9 are formed using the titanium enolate 1. The levels of selectivity vary with the nature of the oxygen protecting group.
Stereoselective conjugate addition of lithium and titanium enolates to γ - Alkoxy enones
Roversi P.Ultimo
Formal Analysis
1996
Abstract
The addition of titanium and lithium enolates 1 and 2 to γ-alkoxy enone 4 occurs in good yield with good stereoselectivities. 3,4 syn - 2,3 syn adducts 7 are obtained starting from the lithium enolate 2, whereas the 3,4 syn - 2,3 anti isomers 9 are formed using the titanium enolate 1. The levels of selectivity vary with the nature of the oxygen protecting group.File in questo prodotto:
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