Several structural and functional neuroimaging studies have shown that the Supplementary Motor Area (SMA) is a ected by tau pathology in patients with Progressive Supranuclear Palsy (PSP). The aim of the study was to investigate the biochemical pro le of SMA in PSP patients, using proton magnetic resonance spectroscopy (1H-MRS). Methods: Sixteen PSP patients and 18 healthy controls participated in this study. 1H-MRS was performed by using a Point RESolving Spectroscopy (PRESS) single-voxel sequence implemented on a 3-T scanner. A voxel of 25 × 25 × 15 mm involving the right and left SMA was acquired in all subjects. Peak areas of N-acetyl- aspartate + N-acetyl-aspartyl-glutamate (NAA), creatine with phosphocreatine (Cr), glycerophosphocho- line + phosphocholine (Cho), glutamate + glutamine (Glx), glutathione (GSH), myo-Inositol (mI) and Scyllo- Inositol (Scyllo) were calculated using a version 6.3-1K of the tting program LCModel. Comparative analysis was performed on both absolute concentrations and ratio values relative to Cr. Results: PSP patients showed a signi cant decrease in Scyllo concentration and Scyllo/Cr ratio values in SMA, compared to controls, whereas no di erence between groups was found for the other ratio values. Of note, the attention and working memory functions were positively related to Scyllo and Scyllo/Cr values in PSP patients. Conclusions: Our study demonstrates that Scyllo and Scyllo/Cr were signi cantly reduced in the SMA of PSP patients. Because Scyllo seems to be able to protect against formation of toxic brils of amyloid-beta fragments and tau oligomers deposition, these preliminary ndings may open new perspectives to investigate Scyllo as a new potential disease-modifying therapy for PSP.
In vivo evidence for decreased scyllo-inositol levels in the supplementary motor area of patients with Progressive Supranuclear Palsy: A proton MR spectroscopy study
Federico Rocca;Manuela Caracciolo;Fabiana Novellino;
2019
Abstract
Several structural and functional neuroimaging studies have shown that the Supplementary Motor Area (SMA) is a ected by tau pathology in patients with Progressive Supranuclear Palsy (PSP). The aim of the study was to investigate the biochemical pro le of SMA in PSP patients, using proton magnetic resonance spectroscopy (1H-MRS). Methods: Sixteen PSP patients and 18 healthy controls participated in this study. 1H-MRS was performed by using a Point RESolving Spectroscopy (PRESS) single-voxel sequence implemented on a 3-T scanner. A voxel of 25 × 25 × 15 mm involving the right and left SMA was acquired in all subjects. Peak areas of N-acetyl- aspartate + N-acetyl-aspartyl-glutamate (NAA), creatine with phosphocreatine (Cr), glycerophosphocho- line + phosphocholine (Cho), glutamate + glutamine (Glx), glutathione (GSH), myo-Inositol (mI) and Scyllo- Inositol (Scyllo) were calculated using a version 6.3-1K of the tting program LCModel. Comparative analysis was performed on both absolute concentrations and ratio values relative to Cr. Results: PSP patients showed a signi cant decrease in Scyllo concentration and Scyllo/Cr ratio values in SMA, compared to controls, whereas no di erence between groups was found for the other ratio values. Of note, the attention and working memory functions were positively related to Scyllo and Scyllo/Cr values in PSP patients. Conclusions: Our study demonstrates that Scyllo and Scyllo/Cr were signi cantly reduced in the SMA of PSP patients. Because Scyllo seems to be able to protect against formation of toxic brils of amyloid-beta fragments and tau oligomers deposition, these preliminary ndings may open new perspectives to investigate Scyllo as a new potential disease-modifying therapy for PSP.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
