Human MENA11a(hMENA11a), an epithelial-associated isoform of the actin binding protein enabled homolog (ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1, HER2, and HER3. Here, we reveal a novel role of this isoform in sustaining cell survival and propose hMENA11a as a marker of HER3 activation and resistance to phosphatidylinositol-3-kinase inhibition therapies.
hMENA11a, a hMENA isoform sending survival signals
Trono P.;
2016
Abstract
Human MENA11a(hMENA11a), an epithelial-associated isoform of the actin binding protein enabled homolog (ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1, HER2, and HER3. Here, we reveal a novel role of this isoform in sustaining cell survival and propose hMENA11a as a marker of HER3 activation and resistance to phosphatidylinositol-3-kinase inhibition therapies.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
