The pivotal role of endoplasmic reticulum in FDG uptake in cancer cells

The present data document that the inhibition of FDG- 6P transport across the reticular membrane slows down tracer release, or, in other words, that a significant fraction of FDG-6P is transported across the reticu- lar membrane into the ER lumen. In this compartment, the accumulated radioactivity can be either released or retained according to the competition between the G6Pase-β-catalyzed hydrolysis or the access to a process- ing pathway able to prevent the metabolite access to the dephosphorylation.