RADIOFREQUENCY ECHOGRAPHIC MULTI SPECTROMETRY (REMS) AS AN ULTRASOUND METHOD FOR BONE QUALITY ASSESSMENT IN PATIENTS WITH TYPE 2 DIABETES MELLITUS World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2024)

Type 2 diabetes mellitus (T2DM) is a chronic, multi factorial disease characterized by persistent hyperglycaemia (high blood glucose levels) as a consequence of insulin resistance, resulting in the development of disabling health complications, such as bone fragility. Scientific literature shows both quality and quantity of bone have a strong relationship with T2DM, contributing to the increased risk of bone fragility fractures compared to nondiabetic subjects. Indeed, these patients, may fracture despite normal or even increased BMD. The bone alterations may be due to the effect of advanced glycosylation end products (AGEs) on collagen fibres and bone cells, this interaction causes a conformational alteration of the structure and of the bone strength. This study aims to use the REMS-based the Fragility Score (FS) parameter to evaluate the effect of T2DM on bone quality microarchitecture. The FS parameter is an indicator of skeletal fragility independent of BMD and ranging from 0–100 (100 indicates the maximum similarity with the fractured model, on the other hand, 0 indicates the maximum similarity with the healthy model).