Anticipatory and target related "match/mismatch" activities of the TPJ: Reply to comments on "Left and right temporal-parietal junctions (TPJs) as "match/mismatch" hedonic machines: A unifying account of TPJ function"

In a 2010 fMRI study [1] that inspired the interpretation of TPJ function detailed in our review [2], we found that during the presentation of central arrow-cues in an endogenous Posner task, the rTPJ was deactivated when cues were informative, i.e. in blocks where cues were valid in 80% of trials, while no similar deactivation was present when cues were non-informative, i.e. when cues were valid in 50% of trials. We proposed that “. . . cue predictiveness sets the level to which the right TPJ is prepared to code a mismatch between expected and actual target locations. The higher the cue predictiveness, the stronger the focusing of attention on the cued location, the stronger the filtering out of uncued location, the stronger the TPJ deactivation, and the weaker the preparation of attentional networks to code a mismatch between expected and actual target location. The level of filtering activity in the TPJ might be regulated by the history of cue effectiveness during task performance” [1]. Though re-summarised in section 5.3. of our review [2], these findings were probably not adequately emphasised in the rest of our manuscript [...]