Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Evangelou, Evangelos; Warren, Helen R.; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P.; Karaman, Ibrahim; Fu Liang Ng,; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N.; Giri, Ayush; Velez Edwards, Digna R.; Sun, Yan V.; Cho, Kelly; Michael Gaziano, J.; Wilson, Peter W. F.; Tsao, Philip S.; Kovesdy, Csaba P.; Esko, Tonu; Mägi, Reedik; Milani, Lili; Almgren, Peter; Boutin, Thibaud; Debette, Stéphanie; Ding, Jun; Giulianini, Franco; Holliday, Elizabeth G.; Jackson, Anne U.; Li-Gao, Ruifang; Lin, Wei-Yu; Luan, Jian’An; Mangino, Massimo; Oldmeadow, Christopher; Bram Peter Prins,; Qian, Yong; Sargurupremraj, Muralidharan; Shah, Nabi; Surendran, Praveen; Thériault, Sébastien; Verweij, Niek; Willems, Sara M.; Zhao, Jing-Hua; Amouyel, Philippe; Connell, John; Renée de Mutsert,; Doney, Alex S. F.; Farrall, Martin; Menni, Cristina; Morris, Andrew D.; Noordam, Raymond; Paré, Guillaume; Poulter, Neil R.; Shields, Denis C.; Stanton, Alice; Thom, Simon; Abecasis, Gonçalo; Amin, Najaf; Arking, Dan E.; Ayers, Kristin L.; Barbieri, Caterina M.; Batini, Chiara; Bis, Joshua C.; Blake, Tineka; Bochud, Murielle; Boehnke, Michael; Boerwinkle, Eric; Boomsma, Dorret I.; Bottinger, Erwin P.; Braund, Peter S.; Brumat, Marco; Campbell, Archie; Campbell, Harry; Chakravarti, Aravinda; Chambers, John C.; Chauhan, Ganesh; Ciullo, Marina; Cocca, Massimiliano; Collins, Francis; Cordell, Heather J.; Davies, Gail; de Borst, Martin H.; de Geus, Eco J.; Deary, Ian J.; Deelen, Joris; Fabiola Del Greco, M.; Cumhur Yusuf Demirkale,; Dörr, Marcus; Ehret, Georg B.; Elosua, Roberto; Enroth, Stefan; Mesut Erzurumluoglu, A.; Ferreira, Teresa; Frånberg, Mattias; Franco, Oscar H.; Gandin, Ilaria; Gasparini, Paolo; Giedraitis, Vilmantas; Gieger, Christian; Girotto, Giorgia; Goel, Anuj; Gow, Alan J.; Gudnason, Vilmundur; Guo, Xiuqing; Gyllensten, Ulf; Hamsten, Anders; Harris, Tamara B.; Harris, Sarah E.; Hartman, Catharina A.; Havulinna, Aki S.; Hicks, Andrew A.; Hofer, Edith; Hofman, Albert; Hottenga, Jouke-Jan; Huffman, Jennifer E.; Hwang, Shih-Jen; Ingelsson, Erik; James, Alan; Jansen, Rick; Jarvelin, Marjo-Riitta; Joehanes, Roby; Johansson, Åsa; Johnson, Andrew D.; Joshi, Peter K.; Jousilahti, Pekka; Wouter Jukema, J.; Jula, Antti; Kähönen, Mika; Kathiresan, Sekar; Keavney, Bernard D.; Khaw, Kay-Tee; Knekt, Paul; Knight, Joanne; Kolcic, Ivana; Kooner, Jaspal S.; Koskinen, Seppo; Kristiansson, Kati; Kutalik, Zoltan; Laan, Maris; Larson, Marty; Launer, Lenore J.; Lehne, Benjamin; Lehtimäki, Terho; Liewald, David C. M.; Lin, Li; Lind, Lars; Lindgren, Cecilia M.; Liu, Yongmei; Loos, Ruth J. F.; Lopez, Lorna M.; Yingchang, Lu; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Mamasoula, Chrysovalanto; Marrugat, Jaume; Marten, Jonathan; Milaneschi, Yuri; Morgan, Anna; Morris, Andrew P.; Morrison, Alanna C.; Munson, Peter J.; Nalls, Mike A.; Nandakumar, Priyanka; Nelson, Christopher P.; Niiranen, Teemu; Nolte, Ilja M.; Nutile, Teresa; Oldehinkel, Albertine J.; Oostra, Ben A.; O’Reilly, Paul F.; Org, Elin; Padmanabhan, Sandosh; Palmas, Walter; Palotie, Aarno; Pattie, Alison; Penninx, Brenda W. J. H.; Perola, Markus; Peters, Annette; Polasek, Ozren; Pramstaller, Peter P.; Quang Tri Nguyen,; Raitakari, Olli T.; Ren, Meixia; Rettig, Rainer; Rice, Kenneth; Ridker, Paul M.; Ried, Janina S.; Riese, Harriëtte; Ripatti, Samuli; Robino, Antonietta; Rose, Lynda M.; Rotter, Jerome I.; Rudan, Igor; Ruggiero, Daniela; Saba, Yasaman; Sala, Cinzia F.; Salomaa, Veikko; Samani, Nilesh J.; Sarin, Antti-Pekka; Schmidt, Reinhold; Schmidt, Helena; Shrine, Nick; Siscovick, David; Smith, Albert V.; Snieder, Harold; Sõber, Siim; Sorice, Rossella; Starr, John M.; Stott, David J.; Strachan, David P.; Strawbridge, Rona J.; Sundström, Johan; Swertz, Morris A.; Taylor, Kent D.; Teumer, Alexander; Tobin, Martin D.; Tomaszewski, Maciej; Toniolo, Daniela; Traglia, Michela; Trompet, Stella; Tuomilehto, Jaakko; Tzourio, Christophe; Uitterlinden, André G.; Vaez, Ahmad; van der Most, Peter J.; van Duijn, Cornelia M.; Vergnaud, Anne-Claire; Verwoert, Germaine C.; Vitart, Veronique; Völker, Uwe; Vollenweider, Peter; Vuckovic, Dragana; Watkins, Hugh; Wild, Sarah H.; Willemsen, Gonneke; Wilson, James F.; Wright, Alan F.; Yao, Jie; Zemunik, Tatijana; Zhang, Weihua; Attia, John R.; Butterworth, Adam S.; Chasman, Daniel I.; Conen, David; Cucca, Francesco; Danesh, John; Hayward, Caroline; Howson, Joanna M. M.; Laakso, Markku; Lakatta, Edward G.; Langenberg, Claudia; Melander, Olle; Mook-Kanamori, Dennis O.; Palmer, Colin N. A.; Risch, Lorenz; Scott, Robert A.; Scott, Rodney J.; Sever, Peter; Spector, Tim D.; Pim van der Harst,; Wareham, Nicholas J.; Zeggini, Eleftheria; Levy, Daniel; Munroe, Patricia B.; Newton-Cheh, Christopher; Brown, Morris J.; Metspalu, Andres; Hung, Adriana M.; O’Donnell, Christopher J.; Edwards, Todd L.; the Million Veteran Program,; Psaty, Bruce M.; Tzoulaki, Ioanna; Barnes, Michael R.; Wain, Louise V.; Elliott, Paul; Caulfield, and Mark J.

doi:10.1101/198234

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.