Abstract 2977: Novel HSP90 inhibitors with senolytic activity for a targeted therapy in a hormone-induced breast cancer senescence model

Background: The research into senescent cells, particularly their accumulation and contribution to aging and age-related diseases, has gained significant momentum in recent years. This interest is primarily driven by findings in mouse models, where the excessive buildup of senescent cells is linked to various age-related pathologies. Consequently, there has been a concerted effort in the scientific community to identify and develop senolytics. A notable development in this field is the identification of senolytics within the class of HSP90 inhibitors. These inhibitors, initially investigated for their potential in cancer therapy, have been repurposed due to their high selectivity for senescent cells. Our research has led to new compounds with mild inhibitory activity against HSP90α in response to these challenges. These compounds stand out for their lack of toxic side effects and their demonstrated senolytic activity across multiple cellular models. Objective: The primary objective of this research is to ide