Radiomic reliability assessed on anatomical and diffusion MRI in Autosomal Dominant Polycystic Kidney Disease (ADPKD) patient

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a hereditary disorder characterized by fluidfilled cyst development [1], in which non-cystic tissue is an indicator of peritubular interstitial fibrosis, impacting renal function and its decline [2]. Radiomics has been recently proposed for classification and prediction of ADPKD stage and progression [3,4,5], but suffers from robustness and stability issues. Our study, which is part of a larger project [6], aims to propose a novel framework to identify reproducible and reliable radiomic features in characterizing non-cystic tissue via multi-parametric MRI (mp-MRI), which integrates anatomical images (T1-w, T2-w) and diffusion-weighted imaging (DWI). Three segmentation approaches for non-cystic tissue, from manual to automatic, were studied as a key source of variability. We suggest a new evaluation of radiomic reliability relying on reproducible and informative features.