Plasma-treated water solutions (PTWS) containing reactive oxygen and nitrogen species can be generated by means of different plasma processes. The delivery of these species through PTWS demonstrated useful for the redox control of many physiological and pathological states, including cancer. Many critical aspects need to be considered in the study of these liquids, namely: the plasma process, the choice of the liquid to be treated, its analysis and the experimen-tal protocols to test its biological effects. Flaws and inaccuracies in each of these steps actually limit the prevision of the clinical efficacy and impair the comparison of results among different laboratories. The aim of this short review is to offer an overall view on the topic, with highlights on the critical aspects in the generation, characterization and use of liquids processed by plasma to selectively attack cancer cells.

Critical Aspects in Generation, Analysis, and In Vitro Testing of RONS in Plasma-Treated Water Solutions for Cancer Treatments

Fracassi, Francesco;Favia, Pietro;Gristina, Roberto;Sardella, Eloisa
Ultimo
2021

Abstract

Plasma-treated water solutions (PTWS) containing reactive oxygen and nitrogen species can be generated by means of different plasma processes. The delivery of these species through PTWS demonstrated useful for the redox control of many physiological and pathological states, including cancer. Many critical aspects need to be considered in the study of these liquids, namely: the plasma process, the choice of the liquid to be treated, its analysis and the experimen-tal protocols to test its biological effects. Flaws and inaccuracies in each of these steps actually limit the prevision of the clinical efficacy and impair the comparison of results among different laboratories. The aim of this short review is to offer an overall view on the topic, with highlights on the critical aspects in the generation, characterization and use of liquids processed by plasma to selectively attack cancer cells.
2021
Istituto di Nanotecnologia - NANOTEC
cancer therapy
colorimetric detection
plasma medicine
plasma-liquids interactions
plasma-treated water solutions
reactive oxygen and nitrogen species
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/519745
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