An appraisal of neuroimmune changes and potential benefits of osteopathic manipulative treatment integration with therapeutic management of post COVID-19 condition: A literature review

The health challenge and the socio-economic burden that marked the COVID-19 pandemic have long been under control, although the World Health Organization (WHO) data paint a clear picture of the difficulties faced over the past four years. However, the reduction in the incidence and severity of SARS-CoV-2 infection has given way to the progressive appearance of clinical signs and symptoms related to COVID-19, which can persist for months following the resolution of the acute phase. This condition has been identified by WHO as “post COVID-19 condition” (PCC), and it currently represents one of the main health and social challenges to which the scienti fic community is called to respond. The best way to successfully manage patients affected by PCC still chal lenging. Recent evidence regarding the pathophysiological hypotheses underlying PCC nevertheless allows us to understand the mechanisms involved and to hypothesise a role for OMT in the therapeutic management of the PCC patient. This review aimed at evaluating the possible role of OMT as a complementary and integrative practice in favouring beneficial autonomic, haemodynamic and immune modifications potentially correlated to the pathogenesis of PCC.