Structure-based targeting of the lipid A-modifying enzyme PmrC to contrast colistin resistance in Acinetobacter baumannii

Antimicrobial-resistant pathogens are an ongoing threat tohuman and animal health. According to the World Health Organization (WHO),colistin is considered the last resort antibiotic against human infections dueto multidrug-resistant Gram-negative organisms—including Acinetobacterbaumanni, a priority-1 pathogen. Despite colistin being considered a last resortantibiotic, transferable bacterial resistance to this drug has been reported inhumans and animals. This makes addressing colistin resistance a critical priorityin public health efforts. The large PetN transferase membrane protein PmrC isresponsible for colistin resistance due to its catalysed modification of lipid A ofthe external membrane. Despite its importance, this potential drug target wasnever characterised at a molecular level (PDF) Structure-based targeting of the lipid A-modifying enzyme PmrC to contrast colistin resistance in Acinetobacter baumannii. Available from: https://www.researchgate.net/publication/386878267_Structure-based_targeting_of_the_lipid_A-modifying_enzyme_PmrC_to_contrast_colistin_resistance_in_Acinetobacter_baumannii#fullTextFileContent [accessed Dec 19 2024].