Sponges are considered the most promising marine organisms as a source of natural products for applications in biotechnology and pharmacological, nutraceutical and cosmeceutical fields. Here we focused our attention on the species Cacospongia mollior, previously collected in the Gulf of Naples and explored for its abundance in associated microorganisms. Several natural compounds were previously isolated from this species with cytotoxic activity against solid tumors but never on melanoma, considered the most aggressive and deadly type of skin cancer. Bioassay-guided fractionation was applied, leading to an enriched fraction of C. mollior able to induce cell death in human melanoma epithelial cell line (A2058) with an IC50 of 0.4 μg mL-1. Through 1H-NMR and mass spectrometry, we identified and characterized the new cytotoxic pyrroleterpene molliorin F. Overall, our findings provide the first evaluation of this new anti-cancer compound from the marine sponge C. mollior, as new potential drug candidate for the melanoma treatment.

Identification of the New Cytotoxic Pyrrole-Terpene Molliorin F from the Mediterranean Sponge Cacospongia Mollior

Gambera, Giovanni;Fontana, Angelo;Nuzzo, Genoveffa;
2024

Abstract

Sponges are considered the most promising marine organisms as a source of natural products for applications in biotechnology and pharmacological, nutraceutical and cosmeceutical fields. Here we focused our attention on the species Cacospongia mollior, previously collected in the Gulf of Naples and explored for its abundance in associated microorganisms. Several natural compounds were previously isolated from this species with cytotoxic activity against solid tumors but never on melanoma, considered the most aggressive and deadly type of skin cancer. Bioassay-guided fractionation was applied, leading to an enriched fraction of C. mollior able to induce cell death in human melanoma epithelial cell line (A2058) with an IC50 of 0.4 μg mL-1. Through 1H-NMR and mass spectrometry, we identified and characterized the new cytotoxic pyrroleterpene molliorin F. Overall, our findings provide the first evaluation of this new anti-cancer compound from the marine sponge C. mollior, as new potential drug candidate for the melanoma treatment.
2024
Istituto di Chimica Biomolecolare - ICB - Sede Pozzuoli
Istituto di Chimica Biomolecolare - ICB - Sede Secondaria Catania
Biotechnology; Cytotoxicity; Marine natural products; Melanoma; Molliorin; Sesterterpenoids
File in questo prodotto:
File Dimensione Formato  
Identification of the new cytotoxic pyrrole-terpene Molliorin F.pdf

accesso aperto

Descrizione: Identification of the New Cytotoxic Pyrrole-Terpene Molliorin F from the Mediterranean Sponge Cacospongia Mollior
Tipologia: Versione Editoriale (PDF)
Licenza: Creative commons
Dimensione 786.31 kB
Formato Adobe PDF
786.31 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/526417
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact