Osteointegration of yttria stabilised zirconia (YSTZ), either coated with bioactive glass named RKKP bioglazeâ (RKKP) or uncoated, was evaluated in an animal model. RKKP-coated and uncoated (controls) YSTZ cylinders were implanted in the distal femoral epiphyses of 14 Sprague Dawley rats under general anaesthesia. At the experimental times of 30 and 60 days after sacrifice, histomorphometry and SEM microanalysis were performed on methylmetacrylate-embedded undecalcified sections to determine the osteointegration rate. At 30 days, a significantly higher affinity index was demonstrated in vivo by histomorphometric evaluation in RKKPcoated versus uncoated YSTZ implants (p<0.05); at 60 days, the coated implants behaved better than controls (affinity index of +32%), but the difference observed lay within the statistical uncertainty. SEM analysis demonstrated better bone adhesion to the material in RKKPcoated YSTZ at both 30 and 60 days. These findings suggest that YSTZ coated with the bioactive glass named RKKPâ enhances osteointegration of ceramics.
Osteointegration of bioactive glass-coated zirconia in healthy bone: an in vivo evaluation
2002
Abstract
Osteointegration of yttria stabilised zirconia (YSTZ), either coated with bioactive glass named RKKP bioglazeâ (RKKP) or uncoated, was evaluated in an animal model. RKKP-coated and uncoated (controls) YSTZ cylinders were implanted in the distal femoral epiphyses of 14 Sprague Dawley rats under general anaesthesia. At the experimental times of 30 and 60 days after sacrifice, histomorphometry and SEM microanalysis were performed on methylmetacrylate-embedded undecalcified sections to determine the osteointegration rate. At 30 days, a significantly higher affinity index was demonstrated in vivo by histomorphometric evaluation in RKKPcoated versus uncoated YSTZ implants (p<0.05); at 60 days, the coated implants behaved better than controls (affinity index of +32%), but the difference observed lay within the statistical uncertainty. SEM analysis demonstrated better bone adhesion to the material in RKKPcoated YSTZ at both 30 and 60 days. These findings suggest that YSTZ coated with the bioactive glass named RKKPâ enhances osteointegration of ceramics.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
