Biosensing platforms based on silicon nanostructures: A critical review

Biosensors are revolutionizing the health-care systems worldwide, permitting to survey several diseases, even at their early stage, by using different biomolecules such as proteins, DNA, and other biomarkers. However, these sensing approaches are still scarcely diffused outside the specialized medical and research facilities. Silicon is the undiscussed leader of the whole microelectronics industry, and novel sensors based on this material may completely change the health-care scenario. In this review, we will show how novel sensing platforms based on Si nanostructures may have a disruptive impact on applications with a real commercial transfer. A critical study for the main Si-based biosensors is herein presented with a comparison of their advantages and drawbacks. The most appealing sensing devices are discussed, starting from electronic transducers, with Si nanowires field-effect transistor (FET) and porous Si, to their optical alternatives, such as effective optical thickness porous silicon, photonic crystals, luminescent Si quantum dots, and finally luminescent Si NWs. All these sensors are investigated in terms of working principle, sensitivity, and selectivity with a specific focus on the possibility of their industrial transfer, and which ones may be preferred for a medical device.