High-precision biosensors for single or few molecules detection play a central role in numerous key fields, such as environmental monitoring and healthcare for early-stage disease diagnosis. In the last decade, laser biosensors have been investigated as proofs of concept, and several technologies have been proposed. Here we propose a demonstration of polymeric whispering gallery microlasers as biosensors for detecting proteins at low concentrations. Free space microlasers have the great advantage of working without any need for waveguiding for input excitation or output signal detection. The photonic microsensors can be easily patterned on microscope slides and operate in air and solution. We could detect down to 400 pg of protein without specific binding, and few tens of pg/mL with specific binding.

Free space whispering gallery mode microlasers as highly sensitive biosensors

Ferretti Stefano;Capocefalo Angela;Gentilini Silvia;Conti Claudio;Cortese Barbara;Bearzi Claudia;Rizzi Roberto;Ghofraniha Neda
2024

Abstract

High-precision biosensors for single or few molecules detection play a central role in numerous key fields, such as environmental monitoring and healthcare for early-stage disease diagnosis. In the last decade, laser biosensors have been investigated as proofs of concept, and several technologies have been proposed. Here we propose a demonstration of polymeric whispering gallery microlasers as biosensors for detecting proteins at low concentrations. Free space microlasers have the great advantage of working without any need for waveguiding for input excitation or output signal detection. The photonic microsensors can be easily patterned on microscope slides and operate in air and solution. We could detect down to 400 pg of protein without specific binding, and few tens of pg/mL with specific binding.
2024
Istituto dei Sistemi Complessi - ISC
Istituto di Nanotecnologia - NANOTEC - Sede Secondaria Roma
Istituto di Tecnologie Biomediche - ITB
Whispering gallery mode microlasers, highly sensitive biosensors
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/539371
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