Background: Plant cytoplasmic GAPDH undergoes nitrosylation and glutathionylation. Results: GSNO triggers mainly nitrosylation of Arabidopsis GAPDH, which can be denitrosylated by GSH but not by thioredoxins. Conclusion: The extent of GAPDH nitrosylation is dependent on the [GSH]/[GSNO] ratio but independent of the [GSH]/[GSSG] ratio. Significance: The mechanisms of GAPDH nitrosylation are delineated, and the prominent role of glutathione is established. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Mechanisms of nitrosylation and denitrosylation of cytoplasmic glyceraldehyde-3-phosphate dehydrogenase from Arabidopsis thaliana
Festa M.;
2013
Abstract
Background: Plant cytoplasmic GAPDH undergoes nitrosylation and glutathionylation. Results: GSNO triggers mainly nitrosylation of Arabidopsis GAPDH, which can be denitrosylated by GSH but not by thioredoxins. Conclusion: The extent of GAPDH nitrosylation is dependent on the [GSH]/[GSNO] ratio but independent of the [GSH]/[GSSG] ratio. Significance: The mechanisms of GAPDH nitrosylation are delineated, and the prominent role of glutathione is established. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.File in questo prodotto:
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