Saliva Proteome of Primary Sclerosing Cholangitis: A Pilot Study to demonstrate its clinical utility

Primary sclerosing cholangitis (PSC) is a rare chronic inflammatory liver disease characterized by biliary strictures and cholestasis. We analysed the saliva proteome to discover proteins that could be used as novel markers for a non-invasive screening and diagnosis of PSC. We identified 25 differentially expressed proteins in PSC patients when compared to the healthy control group. Among them, disulfide-isomerase A3 and peroxiredoxin-5 exhibited an area under the curve values of 0.900 and 0.865, respectively, suggesting these saliva proteins as good discriminators between the two groups.