Alcohol-Induced Oxidative Stress in Health and Disease

Alcohol abuse is a global public health concern, with its impact extending beyond social and behavioral consequences to great physiological effects. Among these, oxidative stress plays a critical role in alcohol-related pathophysiology, influencing a wide range of health situations, from liver disorder to neurodegeneration. This Special Issue, “Alcohol-Induced Oxidative Stress in Health and Disease", published in Antioxidants, brings together pioneering research that investigates the mechanisms of alcohol-induced oxidative damage, its implications for human health, and possible therapeutic interventions. The aim of this collection was extensive, embracing both basic and clinical research. Contributions from important experts provided insights into how alcohol abuse disrupts redox homeostasis, the role of antioxidant defense mechanisms, and novel approaches to mitigate oxidative damage. The studies compiled herein highlighted the importance of understanding oxidative stress as a central process in alcohol-related diseases. They offered perspectives on how antioxidant therapies may serve as potential therapeutic options. The motivation for presenting this Special Issue derived from the growing recognition of oxidative stress as a crucial mediator of alcohol-induced tissue injury. Despite significant advancements, gaps remain in our comprehension of the precise molecular pathways involved and the development of applicable interventions. By assembling assorted research articles, we aimed to provide a comprehensive reference that could aid researchers, clinicians, and healthcare professionals in advancing knowledge and improving patient outcomes. This work is intended for a wide audience, including biomedical researchers, clinicians, pharmacologists, toxicologists, and public health professionals attracted by the connection between alcohol metabolism, oxidative stress, and disease evolution. Moreover, this reprint could be a precious tool for students and early-career scientists to extend their understanding of this evolving scenario. The realization of this Special Issue would not have been conceivable without the dedication and expertise of the contributors, whose work has significantly enriched our understanding of alcohol-induced oxidative stress. I sincerely thank all researchers, reviewers, and editorial staff at Antioxidants (MDPI) for their priceless contributions. Their commitment to scientific merit has safeguarded the high quality of this publication. Further, I hope that this collection of studies will inspire more research and promote new strategies for alleviating the adverse health effects of alcohol-induced oxidative stress.