We define a parallel representation of a disease model, concerning the brain, and of sensory-information processing as occurring in the mind of a person affected by a neurodegenerative or neuropsychiatric disease. We consider the recently proposed Krankheit-Operator (K-operator), representing the alteration to the brain connectome, and we join it with the alterations induced at specific points of an artificial neural network, to model the sensory-information processing, classification, and storage within the memory, that are altered in some diseases. We draw the formalism and present a toy model of application, where the disease is represented by the altered weights in a simple neural network. The alteration in the weights of the connectome is mirrored in the alteration of the weights of the neural network. This approach may help model healing strategies within the equivalent artificial neural network, leading to hints for therapeutic strategies for real-brain networks.

Broken AI. A Test Bench for a Non-invasive Experiment in Computational Neuropsychiatry Joining Krankheit-Operator and Artificial Intelligence

Mannone, M
;
Ribino, P
2025

Abstract

We define a parallel representation of a disease model, concerning the brain, and of sensory-information processing as occurring in the mind of a person affected by a neurodegenerative or neuropsychiatric disease. We consider the recently proposed Krankheit-Operator (K-operator), representing the alteration to the brain connectome, and we join it with the alterations induced at specific points of an artificial neural network, to model the sensory-information processing, classification, and storage within the memory, that are altered in some diseases. We draw the formalism and present a toy model of application, where the disease is represented by the altered weights in a simple neural network. The alteration in the weights of the connectome is mirrored in the alteration of the weights of the neural network. This approach may help model healing strategies within the equivalent artificial neural network, leading to hints for therapeutic strategies for real-brain networks.
2025
Istituto di Calcolo e Reti ad Alte Prestazioni - ICAR - Sede Secondaria Palermo
Artificial neural network,
AI applications,
Brain connectome,
Neuropsychiatric disease
eurodegenerative disease.
File in questo prodotto:
File Dimensione Formato  
AIMH_2025_Proceedings.pdf

accesso aperto

Licenza: Creative commons
Dimensione 365.21 kB
Formato Adobe PDF
365.21 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/547002
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact