Despite its physiological importance, no part of human leptin receptor (ObR) has been structurally characterized before. In this issue of Structure, Carpenter et al. report the crystal structure of the leptin-binding domain of human ObR in complex with the Fab fragment of an ObR-blocking monoclonal antibody (9F8 mAb). © 2012 Elsevier Ltd All rights reserved.
Ob-Stopping Obesity, Metabolic and Immune-Mediated Disorders
De Rosa,Veronica
2012
Abstract
Despite its physiological importance, no part of human leptin receptor (ObR) has been structurally characterized before. In this issue of Structure, Carpenter et al. report the crystal structure of the leptin-binding domain of human ObR in complex with the Fab fragment of an ObR-blocking monoclonal antibody (9F8 mAb). © 2012 Elsevier Ltd All rights reserved.File in questo prodotto:
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