Considering the importance of the pH in modulating annexin activities, we here reassessed the pH dependency (range 4.6-7.4) of the binding of the calcium by human annexin A4 (hAnxA4) and determined its structure from crystals obtained in acidic conditions at nearly atomic resolution in media containing different calcium concentrations.
Computational, crystallographic, and biophysical characterizations provide insights into calcium and phosphate binding by human annexin A4
Vitagliano Luigi;Ruggiero Alessia
2025
Abstract
Considering the importance of the pH in modulating annexin activities, we here reassessed the pH dependency (range 4.6-7.4) of the binding of the calcium by human annexin A4 (hAnxA4) and determined its structure from crystals obtained in acidic conditions at nearly atomic resolution in media containing different calcium concentrations.File in questo prodotto:
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