Histone Methyltransferase SETD2: A Key Player in Cardiometabolic HFpEF

Heart failure with preserved ejection fraction (HFpEF) is a prevalent and complex form of heart failure (HF), characterized by impaired diastolic function, increased myocardial stiffness, and preserved systolic function.1 It accounts for at least half of all HF cases and is expected to become the most common form in the near future. HFpEF is particularly prevalent among older adults, women, and individuals with comorbidities such as obesity, diabetes, and hypertension.2 Despite its significant morbidity and mortality, HFpEF still lacks effective treatments, unlike heart failure with reduced ejection fraction.