Supramolecular Materials based on Cyclodextrins: From Hybrids to Nano-photosensitizers for Health and Sustainability

In the landscape of the design and applications of innovative materials based on cyclodextrins, self-assembly processes involving cyclodextrins with other molecular or metallic components (i.e. drugs, metal nanoparticles and photosensitisers) play a key role to obtain materials with tailored properties1. In this keynote, last results from our Lab (SuNforHeOS) on supramolecular materials made with amphiphilic, polymeric and trade cyclodextrins (i.e. Captisol􀂓) for anticancer2, antiinflammatory and antimicrobial photodynamic therapy will be reviewed3.New insights on delivery, capture and sensing of biomarkers of high-burden diseases by using cyclodextrins-based hybrid nanoconstructs will be reported4,5. Finally, recent outcomes on magnetic cyclodextrins with water remediation properties will be discussed6. Altogether, these supramolecular cyclodextrin materials with high biocompatibility and activity both in vitro and in some cases even in vivo could find promising applications in personalized medicine treatments and be relocated for applications in environment sustainability as pollutants monitoring and sensing.