The planning of radiation oncology treatment is made more dy- namic and individualized by Artificial Intelligence (AI). Routine radiotherapy practice applies normative procedures indifferent to patient-specific parameters such as tumor volume, patient anatomy, and heterogeneity in the delineation of treatment response. Inade- quate and over-radiation treatment is the most prevalent outcome. Further, with the inclusion of AI, it can facilitate enhancing the healthcare industry through optimizing radiotherapy using an array of patient information such as molecular profiles and imaging data. The product offers an end-to-end AI-driven solution to all aspects of radiotherapy, from initial consultation (diagnosis) to adaptive treatment planning. All the sub-system parts like tumour and organ segmentation using Convolutional Neural Networks (CNNs), radiosensitivity esti- mation using machine learning algorithms, and real-time dose adap- tation tools are part of the framework to achieve accuracy-efficiency trade-off in optimized radiotherapy. Moreover, aside from the tech- nical, this book focuses on ethics and social aspects like data privacy, GDPR compliance, and explainability using interpretability meth- ods with saliency maps. Comparative analysis demonstrates im- provements in target accuracy, planning time, and patient-specific adjustability over conventional methods. Finally, the research aims to bridge the gap between high technology innovation and ethically sound clinical application, promoting more efficient and equitable cancer treatment. The findings demonstrate that AI-aided planning significantly enhances precision while reducing man-hours, with a clear path for secure and scalable implementation in the clinic.

AI-Driven Personalized Radiotherapy Planning

Marco Pota;
2025

Abstract

The planning of radiation oncology treatment is made more dy- namic and individualized by Artificial Intelligence (AI). Routine radiotherapy practice applies normative procedures indifferent to patient-specific parameters such as tumor volume, patient anatomy, and heterogeneity in the delineation of treatment response. Inade- quate and over-radiation treatment is the most prevalent outcome. Further, with the inclusion of AI, it can facilitate enhancing the healthcare industry through optimizing radiotherapy using an array of patient information such as molecular profiles and imaging data. The product offers an end-to-end AI-driven solution to all aspects of radiotherapy, from initial consultation (diagnosis) to adaptive treatment planning. All the sub-system parts like tumour and organ segmentation using Convolutional Neural Networks (CNNs), radiosensitivity esti- mation using machine learning algorithms, and real-time dose adap- tation tools are part of the framework to achieve accuracy-efficiency trade-off in optimized radiotherapy. Moreover, aside from the tech- nical, this book focuses on ethics and social aspects like data privacy, GDPR compliance, and explainability using interpretability meth- ods with saliency maps. Comparative analysis demonstrates im- provements in target accuracy, planning time, and patient-specific adjustability over conventional methods. Finally, the research aims to bridge the gap between high technology innovation and ethically sound clinical application, promoting more efficient and equitable cancer treatment. The findings demonstrate that AI-aided planning significantly enhances precision while reducing man-hours, with a clear path for secure and scalable implementation in the clinic.
2025
Istituto di Calcolo e Reti ad Alte Prestazioni - ICAR - Sede Secondaria Napoli
Radiotherapy, Artificial Intelligence, Machine Learning, Tumor Segmentation, Convolutional Neural Networks, Healthcare, Adaptive treatment, Dose prediction, Deep Learning, Data privacy, GDPR Compliance
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/562504
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