The traditional clinical and histopathological features of melanoma have recently been integrated with the expanding landscape of genomic alterations. Cutaneous melanomas arising on sun-exposed skin and those on sun-shielded or partially exposed skin, mucosal and uveal melanomas, differ in clinical and histologic presentation, as well as in prooncogenic driver mutations and mutator mechanisms that account for distinct pathogeneses. Hence, melanoma can be considered a family of different molecular lesions. The assessment of genetic differences among melanoma subtypes is critical for planning effective systemic therapies, and has potential diagnostic and/or prognostic value.
Melanoma: Pathology and genetics
Palmieri G.;
2018
Abstract
The traditional clinical and histopathological features of melanoma have recently been integrated with the expanding landscape of genomic alterations. Cutaneous melanomas arising on sun-exposed skin and those on sun-shielded or partially exposed skin, mucosal and uveal melanomas, differ in clinical and histologic presentation, as well as in prooncogenic driver mutations and mutator mechanisms that account for distinct pathogeneses. Hence, melanoma can be considered a family of different molecular lesions. The assessment of genetic differences among melanoma subtypes is critical for planning effective systemic therapies, and has potential diagnostic and/or prognostic value.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
