Optimizing a Fully-packaged SOI-based Sensor: Microfluidic Flow and Antibody Immobilization Approaches

We present the integration and experimental results of functionalization tests on a novel SOI-based photonic sensor designed for real-time monitoring of aqueous solutions. The device exploits an interferometric architecture to detect refractive index variations with high sensitivity and reliability. To enhance system stability and robustness, a microfluidic platform was integrated, effectively compensating for temperature-induced drifts and mitigating undesired phase shifts caused by external perturbations. The functionalization process under flow conditions, demonstrates effective antibody immobilization on the sensor surface, highlighting its potential for reliable specific detection.