Patients who have undergone kidney transplantation are at an increased risk of developing fractures due to a combination of factors related to both the transplant procedure and the chronic use of immunosuppressive therapy [1]. These therapies, especially corticosteroids [1], contribute to bone mineral density (BMD) loss and altered bone metabolism, leading to a higher incidence of osteoporosis and fractures. Additionally, changes in calcium and phosphate homeostasis, along with reduced physical activity post-transplantation, further exacerbate bone fragility. Many kidney transplant recipients (KTRs) also have pre-existing conditions, such as osteoporosis or chronic kidney disease (CKD), which significantly elevate their fracture risk [3, 4]. Fractures in these patients not only lead to significant morbidity and a reduced quality of life, but also increase mortality rates due to complications such as infections or prolonged hospitalizations. Despite the high incidence of bone-related complications, fracture prevention and management strategies in KTRs remain suboptimal. Given the significant burden posed by fractures in this group, there is a growing need for reliable tools to assess fracture risk and implement early interventions. Fracture risk assessment and managem
ABS0511 FRACTURE RISK ASSESSMENT IN KIDNEY TRANSPLANT RECIPIENTS: THE ROLE OF REMS TECHNOLOGY IN IDENTIFYING HIGH-RISK PATIENTS FOR EARLY INTERVENTION AND PREVENTION
Lombardi, F. A.Membro del Collaboration Group
;Stomaci, C.;Casciaro, E.;Di Paola, M.;Conversano, F.;Casciaro, S.
2025
Abstract
Patients who have undergone kidney transplantation are at an increased risk of developing fractures due to a combination of factors related to both the transplant procedure and the chronic use of immunosuppressive therapy [1]. These therapies, especially corticosteroids [1], contribute to bone mineral density (BMD) loss and altered bone metabolism, leading to a higher incidence of osteoporosis and fractures. Additionally, changes in calcium and phosphate homeostasis, along with reduced physical activity post-transplantation, further exacerbate bone fragility. Many kidney transplant recipients (KTRs) also have pre-existing conditions, such as osteoporosis or chronic kidney disease (CKD), which significantly elevate their fracture risk [3, 4]. Fractures in these patients not only lead to significant morbidity and a reduced quality of life, but also increase mortality rates due to complications such as infections or prolonged hospitalizations. Despite the high incidence of bone-related complications, fracture prevention and management strategies in KTRs remain suboptimal. Given the significant burden posed by fractures in this group, there is a growing need for reliable tools to assess fracture risk and implement early interventions. Fracture risk assessment and managemI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.


