The synthesis of a novel unsymmetrical disulfide-linked adamantane-curcumin conjugate and its supramolecular assembly with amphiphilic cyclodextrin in aqueous dispersion is herein reported. Within the nanoassemblies, a curcumin derivative was dissolved up to 0.14 mg mL-1 in ultrapure water. The derivative was also highly dispersible in other biologically relevant media (e.g., NaCl 0.9 wt% and PBS pH 7.4), and exhibited redox-responsiveness in the presence of glutathione as a reducing agent.
A supramolecular assembly of a disulfide-linked adamantane–curcumin conjugate and amphiphilic cyclodextrin with redox-responsive potential
Zagami R.;Nocito G.;Mazzaglia A.
2026
Abstract
The synthesis of a novel unsymmetrical disulfide-linked adamantane-curcumin conjugate and its supramolecular assembly with amphiphilic cyclodextrin in aqueous dispersion is herein reported. Within the nanoassemblies, a curcumin derivative was dissolved up to 0.14 mg mL-1 in ultrapure water. The derivative was also highly dispersible in other biologically relevant media (e.g., NaCl 0.9 wt% and PBS pH 7.4), and exhibited redox-responsiveness in the presence of glutathione as a reducing agent.File in questo prodotto:
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