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Biphenyl hydroxylated derivatives are positive modulators of human GABAA receptors

M P MASCIA;D FABBRI;M DETTORI;G DELOGU;
2008
2008
Istituto di Chimica Biomolecolare - ICB - Sede Pozzuoli
Istituto di Neuroscienze - IN -
Neuroscience 2008
Washington D.C.
hydroxylated biphenyls
synthesis
GABAa receptor
LGIC receptor
neurdedegenerative
Our results demonstrate that compound 3 (3,3’, 5,5’-tetrabromo-2,2’ biphenyldiol) is, among the others biphenyl hydroxilated derivatives tested, a potent, and selective modulator of the GABAA receptor function and may act on a site different from benzodiazepine recognition site, given that the potentiation of the GABAA receptor is not affected by the benzodiazepine receptor antagonist flumazenil. Behavioural experiments are needed to define the pharmacological profile of this compound.
none
info:eu-repo/semantics/conferenceObject
P MASCIA, M; Fabbri, D; Dettori, M; Cossu, C; Serra, M; Carta, S; Delogu, G; Biggio, G
275
04 Contributo in convegno::04.03 Poster in Atti di convegno
8
04.03 Poster in Atti di convegno
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/66570
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