Potentially bio-active 2-benzazepine, 2-benzazocine, isoquinoline derivatives were selectively synthesized from N-alkyl, N-(o-iodobenzyl)-3-butenamides and a catalytic amount of palladium complexes. The regiochemistry of the annulation leading to seven/eight- or six-membered ring formation can be completely determined varying medium polarity by the addition of water
Palladium-catalyzed cyclization of N-n-butyl, N-(o-iodobenzyl)-3-butenamides: six- versus seven- and eight-membered ring formation
Ferraccioli R;
2002
Abstract
Potentially bio-active 2-benzazepine, 2-benzazocine, isoquinoline derivatives were selectively synthesized from N-alkyl, N-(o-iodobenzyl)-3-butenamides and a catalytic amount of palladium complexes. The regiochemistry of the annulation leading to seven/eight- or six-membered ring formation can be completely determined varying medium polarity by the addition of waterFile in questo prodotto:
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Descrizione: Palladium-catalyzed cyclization of N-n-butyl, N-(o-iodobenzyl)-3-butenamides: six- versus seven- and eight-membered ring formation
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