A novel,straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morpholines has been developed through the regioselective cyclization of diols. Cyclization precursors have been obtained by the ring opening of commercially available chiral epoxides under solidliquid phase transfer catalysis conditions (SL-PTC).
A practical approach to the synthesis of enantiomerically pure 2, 6-disubstituted morpholines under phase transfer catalysis conditions
Penso M
2009
Abstract
A novel,straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morpholines has been developed through the regioselective cyclization of diols. Cyclization precursors have been obtained by the ring opening of commercially available chiral epoxides under solidliquid phase transfer catalysis conditions (SL-PTC).File in questo prodotto:
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