The alpha(v)beta(3) integrin is an adhesion molecule involved in physiological and pathological angiogenesis as well as in tumor invasion and metastasis, and therefore, there is a strong interest in developing novel agents interacting with this molecule. We report the synthesis and characterization of fluorescent alpha(v)beta(3) integrin probes and their use to visualize integrin alpha(v)beta(3) expression on human normal and cancer cells, The fluorescent probes we describe here may be of use for noninvasive imaging of alpha(v)beta(3) integrin expression also hi vivo.
Functionalized Cyclic RGD Peptidomimetics: Conjugable ligands for alpha(v)beta(3) Receptor Imaging
Daniela Arosio;
2009
Abstract
The alpha(v)beta(3) integrin is an adhesion molecule involved in physiological and pathological angiogenesis as well as in tumor invasion and metastasis, and therefore, there is a strong interest in developing novel agents interacting with this molecule. We report the synthesis and characterization of fluorescent alpha(v)beta(3) integrin probes and their use to visualize integrin alpha(v)beta(3) expression on human normal and cancer cells, The fluorescent probes we describe here may be of use for noninvasive imaging of alpha(v)beta(3) integrin expression also hi vivo.File in questo prodotto:
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Descrizione: Functionalized Cyclic RGD Peptidomimetics: Conjugable ligands for alpha(v)beta(3) Receptor Imaging
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