A small library of cyclic RGD pseudopentapeptides incorporating stereoisomeric 6,5- and 7,5-fused bicyclic lactams was synthesized with the aim of developing active and selective integrin antagonists. The solid-phase synthesis and activity of these RGD derivatives is described. The approach led to two of the most active known inhibitors of alphavbeta3 receptor.
Potent Integrin Antagonists from a Small Library of RGD-Including Cyclic Pseudopeptides
Manzoni L;
2001
Abstract
A small library of cyclic RGD pseudopentapeptides incorporating stereoisomeric 6,5- and 7,5-fused bicyclic lactams was synthesized with the aim of developing active and selective integrin antagonists. The solid-phase synthesis and activity of these RGD derivatives is described. The approach led to two of the most active known inhibitors of alphavbeta3 receptor.File in questo prodotto:
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Descrizione: Potent integrin antagonists from a small library of RGD-including cyclic pseudopeptides
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