Functionalized bicyclic lactams serve as building blocks for the synthesis of conformationally constrained peptides. A route to these building blocks is described based on the stereoselective alkylation of an appropriate azabicycloalkane; all possible diastereoisomers can be obtained stereoselectively.
Synthesis of functionalized azabicycloalkane amino acids as dipeptide mimics
Manzoni L;Forni A;
2006
Abstract
Functionalized bicyclic lactams serve as building blocks for the synthesis of conformationally constrained peptides. A route to these building blocks is described based on the stereoselective alkylation of an appropriate azabicycloalkane; all possible diastereoisomers can be obtained stereoselectively.File in questo prodotto:
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Descrizione: Synthesis of functionalized azabicycloalkane amino acids as dipeptide mimics
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