An efficient and operationally simple method for the synthesis of functionalized azaoxobicyclo[X.3.0]alkane amino acids has been devised. The key step is an intramolecular nitrone cycloaddition on 5-allyl- or 5-homoallylproline that was found to be completely regio- and stereoselective.
Functionalised azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition
L Manzoni;D Arosio;
2005
Abstract
An efficient and operationally simple method for the synthesis of functionalized azaoxobicyclo[X.3.0]alkane amino acids has been devised. The key step is an intramolecular nitrone cycloaddition on 5-allyl- or 5-homoallylproline that was found to be completely regio- and stereoselective.File in questo prodotto:
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Descrizione: Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition
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