beta-Hairpin peptides were conformationally stabilized through a 1,4 disubstituted 1,2,3-triazole interstrand linkage. A NMR conformational analysis revealed that the beta-hairpin content depends on the number and position of substituent methylene units of the 1,2,3-triazole ring. These results will allow the design of metabolically stable peptidomimetic analogs of bioactive beta-hairpin peptides.
beta-Hairpin stabilization through an interstrand triazole bridge
Diana DCo-primo
;De Rosa L;D'Andrea LD
2012
Abstract
beta-Hairpin peptides were conformationally stabilized through a 1,4 disubstituted 1,2,3-triazole interstrand linkage. A NMR conformational analysis revealed that the beta-hairpin content depends on the number and position of substituent methylene units of the 1,2,3-triazole ring. These results will allow the design of metabolically stable peptidomimetic analogs of bioactive beta-hairpin peptides.File in questo prodotto:
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Chem Comm 2012.pdf
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