CNR Institutional Research Information System

Analysis of UTRs from nuclear-encoded mRNA targeting the mitochondrion in Metazoa reveals new insights about molecular mechanisms controlling mitochondrial biogenesis

DElia Domenica;Grillo Giorgio
2007
2007
Istituto di Tecnologie Biomediche - ITB
BITS2007 Meeting
Napoli
Mitochondrial biogenesis
nuclear-encoded mitochondrial gene
genome expression
translational control
The structural analyses of UTR sequences investigated have revealed a significant contraction of their average length when compared with values obtained on total cell mRNAs, with a much more marked effect in 5UTRs. We have also found IRESs motifs in the 3UTRs of respiratory genes in human and rodents, as reported in literature, and also in B. taurus, D. rerio and D. melanogaster and in the 3UTRs of mtTFA and EF-Tu mitochondrial factors, in human and others mammals. On the whole these findings suggest that the translational molecular mechanism controlling mitochondrial differentiation is common not only to mammals, but also to other taxonomic groups, and that the coordination of nucleus-mitochondrion expression during the development is mediated at the translation level by IRESs. The importance of translation control on mitochondrial biogenesis and function has been further underlined by results obtained from our analyses on transcripts that incorporate at their 5’ terminus TOP motifs and of INS_SCE motifs in the 3UTRs of respiratory genes mRNAs. INS_SCE has a key role in the stabilization of insulin transcript, a key modulator of insulin production. Our findings suggest a potential coordinated control of insulin secretion and mitochondrial biogenesis that could shed light on the still unknown mechanisms controlling the functional interdependence among glucose-dependent insulin secretion, mitochondrial biogenesis and insulin-mitochondria dependent myogenesis.
none
info:eu-repo/semantics/conferenceObject
DElia Domenica ; Germinario Lucrezia ; Grillo Giorgio
275
04 Contributo in convegno::04.03 Poster in Atti di convegno
2
04.03 Poster in Atti di convegno
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/94700
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact