The palladium-catalyzed intramolecular cyclization of 1-butyl-1(o-iodobenzyl)-3-phenylurea 1 at 80 degrees C in the presence of carbon monoxide at atmospheric pressure gives the corresponding 2,3,4,5-tetrahydro-1H-2,4-benzodiazepine-1,3-dione derivative 2 in 91% yield. Yield and selectivity are strongly affected by the solvent. (
A new and efficient palladium-catalyzed synthesis of a 2,3,4,5-tetrahydro-1H-2,4-benzodiazepine-1,3-dione derivative
Ferraccioli R
1999
Abstract
The palladium-catalyzed intramolecular cyclization of 1-butyl-1(o-iodobenzyl)-3-phenylurea 1 at 80 degrees C in the presence of carbon monoxide at atmospheric pressure gives the corresponding 2,3,4,5-tetrahydro-1H-2,4-benzodiazepine-1,3-dione derivative 2 in 91% yield. Yield and selectivity are strongly affected by the solvent. (File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
prod_200718-doc_44268.pdf
non disponibili
Descrizione: A new and efficient palladium-catalyzed synthesis of a 2,3,4,5-tetrahydro-1H-2,4-benzodiazepine-1,3-dione derivative
Dimensione
101.08 kB
Formato
Adobe PDF
|
101.08 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
