LORIGA, GIOVANNI
LORIGA, GIOVANNI
Istituto di Chimica Biomolecolare - ICB - Sede Pozzuoli
Design and synthesis of a new Non-Covalent Caspase-3 Inhibitor with Neuroprotective Property
2023 Spanu, Pietro; Chandgudge, Ajay; Ulgheri, Fausta; Loriga, Giovanni; Fuggetta, MARIA PIA; M Dolga, Amalia; H Elsinga, Philip; Kopschina Feltes, Paula; J de Vries, Erik F; Domling, Alexander
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction
2023 Asproni, Battistina; Catto, Marco; Loriga, Giovanni; Murineddu, Gabriele; Corona, Paola; Purgatorio, Rosa; Cichero, Elena; Fossa, Paola; Scarano, Naomi; Martínez, Antón L.; Brea, José; Pinna, Gérard A.
Design, synthesis and biological evaluation of 1,5-disubstituted aamino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders
2022 Ulgheri, Fausta; Spanu, Pietro; Deligia, Francesco; Loriga, Giovanni; Fuggetta, MARIA PIA; de Haan, Iris; Chandgudge, Ajay; Groves, Matthew; Domling, Alexander
Biological Effects on μ-Receptors Affinity and Selectivity of Arylpropenyl Chain Structural Modification on Diazatricyclodecane Derivatives
2021 Piras, Sandra; Murineddu, Gabriele; Loriga, Giovanni; Carta, Antonio; Battistello, Enrica; Merighi, Stefania; Gessi, Stefania; Corona, Paola; Asproni, Battistina; Ibba, Roberta; Temml, Veronika; Schuster, Daniela; Pinna, Gérard Aimè
Non-covalent inflammasome-caspase-1 complex inhibitors: New molecules targeting immune and inflammatory disorders including COVID-19
2020 Ulgheri, Fausta; Spanu, Pietro; Deligia, Francesco; Loriga, Giovanni; Fuggetta, MARIA PIA; Morra, Andrea; de Haan, Iris; Chandgudge, Ajay; R Groves, Matthew; Domling, Alexander
Novel therapeutic approach in a multiplicity of neurodegenerative and autoinflammatory pathologies
2019 Spanu, Pietro; Ulgheri, Fausta; Loriga, Giovanni
A New synthetic spiroketal: Antitumor Activity On Murine Melanoma Model In Vivo and MOA In Vitro
2018 Spanu, Pietro; Fuggetta, MARIA PIA; Ulgheri, Fausta; Deligia, Francesco; Loriga, Giovanni; Carta, Paola; Mannu, Alberto; Trotta, Veronica; De Cicco, Rosanna; Barra, Adriano; Zona, Enrica; Morelli, Franco
Novel pyrrolocycloalkylpyrazole analogues as CB1 ligands
2018 Asproni, Battistina; Manca, Ilaria; Pinna, Giansalvo; Cichero, Elena; Fossa, Paola; Murineddu, Gabriele; Lazzari, Paolo; Loriga, Giovanni; Pinna Gerard, A
Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1 receptor ligand antagonists
2018 Murineddu G.; Deligia F.; Ragusa G.; GarciaToscano L.; GomezCanas M.; Asproni B.; Satta V.; Cichero E.; Pazos R.; Fossa P.; Loriga G.; FernandezRuiz J.; Pinna G.A.
Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for ?4 ?2 nACh receptors
2018 Deligia, F; Murineddu, G; Gotti, C; Ragusa, G; Fasoli, F; Sciaccaluga, M; Plutino, S; Fucile, S; Loriga, G; Asproni, B; Pinna, G A
Synthesis, Pharmacological Evaluation, and Docking Studies of Novel Pyridazinone-Based Cannabinoid Receptor Type2 Ligands
2018 Ragusa, Giulio; Bencivenni, Serena; Morales, Paula; Callaway, Tyra; Hurst Dow, P; Asproni, Battistina; Merighi, Stefania; Loriga, Giovanni; Pinna Gerard, A; Reggio Patricia, H; Gessi, Stefania; Murineddu, Gabriele
Novel diazabicycloalkane delta opioid agonists
2015 Loriga G.; Lazzari P.; Manca I.; Ruiu S.; Falzoi M.; Murineddu G.; Bottazzi M.E.H.; Pinna G.; Pinna G.A.
Differential modulation of GABA(A) receptor function by aryl pyrazoles
2014 Mascia, M.P.; Ledda, G.; Orrù, A.; Marongiu, A.; Loriga, G.; Maciocco, E.; Biggio, G.; Ruiu, S.
Tricyclic pyrazoles. Part 6. Benzofuro[3,2-c]pyrazole: A versatile architecture for CB2 selective ligands
2014 Pinna, G; Loriga, G; Lazzari, P; Ruiu, S; Falzoi, M; Frau, S; Pau, A; Murineddu, G; Asproni, B; Pinna, Ga
Novel pyrazole derivatives as neutral CB1 antagonists with significant activity towards food intake
2013 Manca, Ilaria; Mastinu, Andrea; Olimpieri, Francesca; Falzoi, Matteo; Sani, Monica; Ruiu, Stefania; Loriga, Giovanni; Volonterio, Alessandro; Tambaro, Simone; Bottazzi Mirko Emilio, Heiner; Zanda, Matteo; Pinna Gerard, Aime; Lazzari, Paolo
Synthesis and biological evaluation of novel delta (?) opioid receptor ligands with diazatricyclodecane skeletons
2013 Loriga, G; Lazzari, P; Ruiu, S; Marchese, G; Manca, I; Casu, Gl; Dessi, C; Pinna, Ga; Asproni, B; Murineddu, G
Synthesis of tricyclic condensed rings incorporating the pyrazole or isoxazole moieties bonded to a 4-piperidinyl substituent
2013 Pinna G.; Loriga G.; Pinna G.A.; Chelucci G.
Composti farmaceutici Diazabicyclic compounds as opioid receptor agonists
2008 Lazzari, P; Loriga, G; Ruiu, S; Manca, I; Pani, L; Pinna, Ga
Microemulsioni
2008 Lazzari, P; Loriga, G; Ruiu, S; Manca, I; Pani, L; Pinna, Ga
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Design and synthesis of a new Non-Covalent Caspase-3 Inhibitor with Neuroprotective Property | 1-gen-2023 | Spanu, Pietro; Chandgudge, Ajay; Ulgheri, Fausta; Loriga, Giovanni; Fuggetta, MARIA PIA; M Dolga, Amalia; H Elsinga, Philip; Kopschina Feltes, Paula; J de Vries, Erik F; Domling, Alexander | |
| Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction | 1-gen-2023 | Asproni, Battistina; Catto, Marco; Loriga, Giovanni; Murineddu, Gabriele; Corona, Paola; Purgatorio, Rosa; Cichero, Elena; Fossa, Paola; Scarano, Naomi; Martínez, Antón L.; Brea, José; Pinna, Gérard A. | |
| Design, synthesis and biological evaluation of 1,5-disubstituted aamino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders | 1-gen-2022 | Ulgheri, Fausta; Spanu, Pietro; Deligia, Francesco; Loriga, Giovanni; Fuggetta, MARIA PIA; de Haan, Iris; Chandgudge, Ajay; Groves, Matthew; Domling, Alexander | |
| Biological Effects on μ-Receptors Affinity and Selectivity of Arylpropenyl Chain Structural Modification on Diazatricyclodecane Derivatives | 1-gen-2021 | Piras, Sandra; Murineddu, Gabriele; Loriga, Giovanni; Carta, Antonio; Battistello, Enrica; Merighi, Stefania; Gessi, Stefania; Corona, Paola; Asproni, Battistina; Ibba, Roberta; Temml, Veronika; Schuster, Daniela; Pinna, Gérard Aimè | |
| Non-covalent inflammasome-caspase-1 complex inhibitors: New molecules targeting immune and inflammatory disorders including COVID-19 | 1-gen-2020 | Ulgheri, Fausta; Spanu, Pietro; Deligia, Francesco; Loriga, Giovanni; Fuggetta, MARIA PIA; Morra, Andrea; de Haan, Iris; Chandgudge, Ajay; R Groves, Matthew; Domling, Alexander | |
| Novel therapeutic approach in a multiplicity of neurodegenerative and autoinflammatory pathologies | 1-gen-2019 | Spanu, Pietro; Ulgheri, Fausta; Loriga, Giovanni | |
| A New synthetic spiroketal: Antitumor Activity On Murine Melanoma Model In Vivo and MOA In Vitro | 1-gen-2018 | Spanu, Pietro; Fuggetta, MARIA PIA; Ulgheri, Fausta; Deligia, Francesco; Loriga, Giovanni; Carta, Paola; Mannu, Alberto; Trotta, Veronica; De Cicco, Rosanna; Barra, Adriano; Zona, Enrica; Morelli, Franco | |
| Novel pyrrolocycloalkylpyrazole analogues as CB1 ligands | 1-gen-2018 | Asproni, Battistina; Manca, Ilaria; Pinna, Giansalvo; Cichero, Elena; Fossa, Paola; Murineddu, Gabriele; Lazzari, Paolo; Loriga, Giovanni; Pinna Gerard, A | |
| Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1 receptor ligand antagonists | 1-gen-2018 | Murineddu G.; Deligia F.; Ragusa G.; GarciaToscano L.; GomezCanas M.; Asproni B.; Satta V.; Cichero E.; Pazos R.; Fossa P.; Loriga G.; FernandezRuiz J.; Pinna G.A. | |
| Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for ?<inf>4</inf>?<inf>2</inf>nACh receptors | 1-gen-2018 | Deligia, F; Murineddu, G; Gotti, C; Ragusa, G; Fasoli, F; Sciaccaluga, M; Plutino, S; Fucile, S; Loriga, G; Asproni, B; Pinna, G A | |
| Synthesis, Pharmacological Evaluation, and Docking Studies of Novel Pyridazinone-Based Cannabinoid Receptor Type2 Ligands | 1-gen-2018 | Ragusa, Giulio; Bencivenni, Serena; Morales, Paula; Callaway, Tyra; Hurst Dow, P; Asproni, Battistina; Merighi, Stefania; Loriga, Giovanni; Pinna Gerard, A; Reggio Patricia, H; Gessi, Stefania; Murineddu, Gabriele | |
| Novel diazabicycloalkane delta opioid agonists | 1-gen-2015 | Loriga G.; Lazzari P.; Manca I.; Ruiu S.; Falzoi M.; Murineddu G.; Bottazzi M.E.H.; Pinna G.; Pinna G.A. | |
| Differential modulation of GABA(A) receptor function by aryl pyrazoles | 1-gen-2014 | Mascia, M.P.; Ledda, G.; Orrù, A.; Marongiu, A.; Loriga, G.; Maciocco, E.; Biggio, G.; Ruiu, S. | |
| Tricyclic pyrazoles. Part 6. Benzofuro[3,2-c]pyrazole: A versatile architecture for CB2 selective ligands | 1-gen-2014 | Pinna, G; Loriga, G; Lazzari, P; Ruiu, S; Falzoi, M; Frau, S; Pau, A; Murineddu, G; Asproni, B; Pinna, Ga | |
| Novel pyrazole derivatives as neutral CB1 antagonists with significant activity towards food intake | 1-gen-2013 | Manca, Ilaria; Mastinu, Andrea; Olimpieri, Francesca; Falzoi, Matteo; Sani, Monica; Ruiu, Stefania; Loriga, Giovanni; Volonterio, Alessandro; Tambaro, Simone; Bottazzi Mirko Emilio, Heiner; Zanda, Matteo; Pinna Gerard, Aime; Lazzari, Paolo | |
| Synthesis and biological evaluation of novel delta (?) opioid receptor ligands with diazatricyclodecane skeletons | 1-gen-2013 | Loriga, G; Lazzari, P; Ruiu, S; Marchese, G; Manca, I; Casu, Gl; Dessi, C; Pinna, Ga; Asproni, B; Murineddu, G | |
| Synthesis of tricyclic condensed rings incorporating the pyrazole or isoxazole moieties bonded to a 4-piperidinyl substituent | 1-gen-2013 | Pinna G.; Loriga G.; Pinna G.A.; Chelucci G. | |
| Composti farmaceutici Diazabicyclic compounds as opioid receptor agonists | 1-gen-2008 | Lazzari, P; Loriga, G; Ruiu, S; Manca, I; Pani, L; Pinna, Ga | |
| Microemulsioni | 1-gen-2008 | Lazzari, P; Loriga, G; Ruiu, S; Manca, I; Pani, L; Pinna, Ga |